PWAS: proteome-wide association study—linking genes and phenotypes by functional variation in proteins

We introduce Proteome-Wide Association Study (PWAS), a new method for detecting gene-phenotype associations mediated by protein function alterations. PWAS aggregates the signal of all variants jointly affecting a protein-coding gene and assesses their overall impact on the protein’s function using m...

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Detalles Bibliográficos
Autores principales: Brandes, Nadav, Linial, Nathan, Linial, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386203/
https://www.ncbi.nlm.nih.gov/pubmed/32665031
http://dx.doi.org/10.1186/s13059-020-02089-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386203/
https://www.ncbi.nlm.nih.gov/pubmed/32665031
http://dx.doi.org/10.1186/s13059-020-02089-x

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