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PWAS: proteome-wide association study—linking genes and phenotypes by functional variation in proteins
We introduce Proteome-Wide Association Study (PWAS), a new method for detecting gene-phenotype associations mediated by protein function alterations. PWAS aggregates the signal of all variants jointly affecting a protein-coding gene and assesses their overall impact on the protein’s function using m...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386203/ https://www.ncbi.nlm.nih.gov/pubmed/32665031 http://dx.doi.org/10.1186/s13059-020-02089-x |