Impaired B cell anergy is not sufficient to breach tolerance to nuclear antigen in Vκ8/3H9 lupus-prone mice

BACKGROUND: Systemic lupus erythematosus (SLE) is a severe autoimmune disease in which immune tolerance defects drive production of pathogenic anti-nuclear autoantibodies. Anergic B cells are considered a potential source of these autoantibodies due to their autoreactivity and overrepresentation in...

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Detalles Bibliográficos
Autores principales: Manion, Kieran P., Baglaenko, Yuriy, Chang, Nan-Hua, Talaei, Nafiseh, Wither, Joan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386585/
https://www.ncbi.nlm.nih.gov/pubmed/32722684
http://dx.doi.org/10.1371/journal.pone.0236664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386585/
https://www.ncbi.nlm.nih.gov/pubmed/32722684
http://dx.doi.org/10.1371/journal.pone.0236664

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