Infant and adult SCA13 mutations differentially affect Purkinje cell excitability, maturation, and viability in vivo

Mutations in KCNC3, which encodes the Kv3.3 K(+) channel, cause spinocerebellar ataxia 13 (SCA13). SCA13 exists in distinct forms with onset in infancy or adulthood. Using zebrafish, we tested the hypothesis that infant- and adult-onset mutations differentially affect the excitability and viability...

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Detalles Bibliográficos
Autores principales: Hsieh, Jui-Yi, Ulrich, Brittany N, Issa, Fadi A, Lin, Meng-chin A, Brown, Brandon, Papazian, Diane M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386905/
https://www.ncbi.nlm.nih.gov/pubmed/32644043
http://dx.doi.org/10.7554/eLife.57358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386905/
https://www.ncbi.nlm.nih.gov/pubmed/32644043
http://dx.doi.org/10.7554/eLife.57358

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