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Infant and adult SCA13 mutations differentially affect Purkinje cell excitability, maturation, and viability in vivo
Mutations in KCNC3, which encodes the Kv3.3 K(+) channel, cause spinocerebellar ataxia 13 (SCA13). SCA13 exists in distinct forms with onset in infancy or adulthood. Using zebrafish, we tested the hypothesis that infant- and adult-onset mutations differentially affect the excitability and viability...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386905/ https://www.ncbi.nlm.nih.gov/pubmed/32644043 http://dx.doi.org/10.7554/eLife.57358 |