Ovariectomy uncouples lifespan from metabolic health and reveals a sex-hormone-dependent role of hepatic mTORC2 in aging

Inhibition of mTOR (mechanistic Target Of Rapamycin) signaling by rapamycin promotes healthspan and longevity more strongly in females than males, perhaps because inhibition of hepatic mTORC2 (mTOR Complex 2) specifically reduces the lifespan of males. Here, we demonstrate using gonadectomy that the...

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Detalles Bibliográficos
Autores principales: Arriola Apelo, Sebastian I, Lin, Amy, Brinkman, Jacqueline A, Meyer, Emma, Morrison, Mark, Tomasiewicz, Jay L, Pumper, Cassidy P, Baar, Emma L, Richardson, Nicole E, Alotaibi, Mohammed, Lamming, Dudley W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386906/
https://www.ncbi.nlm.nih.gov/pubmed/32720643
http://dx.doi.org/10.7554/eLife.56177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386906/
https://www.ncbi.nlm.nih.gov/pubmed/32720643
http://dx.doi.org/10.7554/eLife.56177

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