FTIR Spectroscopy Detects Intermolecular β-Sheet Formation Above the High Temperature T(m) for Two Monoclonal Antibodies

The temperature-dependent secondary structure of two monoclonal IgG antibodies, anti-IGF1R and anti-TSLP, were examined by transmission mode Fourier Transform Infrared (FTIR) spectroscopy. Anti-IGF1R and anti-TSLP are IgG monoclonal antibodies (mAbs) directed against human Insulin-like Growth Factor...

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Detalles Bibliográficos
Autores principales: Baird, Garrett, Farrell, Chris, Cheung, Jason, Semple, Andrew, Blue, Jeffery, Ahl, Patrick L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387379/
https://www.ncbi.nlm.nih.gov/pubmed/32656609
http://dx.doi.org/10.1007/s10930-020-09907-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387379/
https://www.ncbi.nlm.nih.gov/pubmed/32656609
http://dx.doi.org/10.1007/s10930-020-09907-y

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