Cargando…
In vitro and ex vivo gene expression profiling reveals differential kinetic response of HSPs and UPR genes is associated with PI resistance in multiple myeloma
Extensive inter-individual variation in response to chemotherapy (sensitive vs resistant tumors) is a serious cause of concern in the treatment of multiple myeloma (MM). In this study, we used human myeloma cell lines (HMCLs), and patient-derived CD138+ cells to compare kinetic changes in gene expre...
Autores principales: | Mitra, Amit Kumar, Kumar, Harish, Ramakrishnan, Vijay, Chen, Li, Baughn, Linda, Kumar, Shaji, Rajkumar, S. Vincent, Van Ness, Brian G. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387444/ https://www.ncbi.nlm.nih.gov/pubmed/32724061 http://dx.doi.org/10.1038/s41408-020-00344-9 |
Ejemplares similares
-
secDrug: a pipeline to discover novel drug combinations to kill drug-resistant multiple myeloma cells using a greedy set cover algorithm and single-cell multi-omics
por: Kumar, Harish, et al.
Publicado: (2022) -
Single-Cell Proteomics and Tumor RNAseq Identify Novel Pathways Associated With Clofazimine Sensitivity in PI- and IMiD- Resistant Myeloma, and Putative Stem-Like Cells
por: Kumar, Harish, et al.
Publicado: (2022) -
Molecular signatures of multiple myeloma progression through single cell RNA-Seq
por: Jang, Jin Sung, et al.
Publicado: (2019) -
Anti-Myeloma Activity of Akt Inhibition Is Linked to the Activation Status of PI3K/Akt and MEK/ERK Pathway
por: Ramakrishnan, Vijay, et al.
Publicado: (2012) -
Inhibitor of Apoptosis Proteins (IAPs) as therapeutic targets in Multiple Myeloma (MM)
por: Ramakrishnan, Vijay, et al.
Publicado: (2014)