An NAD(+)-Dependent Deacetylase SIRT7 Promotes HCC Development Through Deacetylation of USP39

Ubiquitin specific protease 39 (USP39), an ortholog of Sad1p in yeast, is essential for spliceosome assembly during pre-mRNA splicing in human. Although it is known that USP39 is upregulated and plays an oncogenic role in hepatocellular carcinoma (HCC), the underlying mechanism remains unknown. The...

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Detalles Bibliográficos
Autores principales: Dong, Ling, Yu, Le, Li, Hui, Shi, Lei, Luo, Zhong, Zhao, Huakan, Liu, Zhaojian, Yin, Guobing, Yan, Xiaohua, Lin, Zhenghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387830/
https://www.ncbi.nlm.nih.gov/pubmed/32711345
http://dx.doi.org/10.1016/j.isci.2020.101351

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387830/
https://www.ncbi.nlm.nih.gov/pubmed/32711345
http://dx.doi.org/10.1016/j.isci.2020.101351

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