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Doxorubicin-induced oxidative and nitrosative stress: Mitochondrial connexin 43 is at the crossroads

Oxidative stress is widely accepted as a key factor of doxorubicin (Doxo)-induced cardiotoxicity. There is evidence to indicate that nitrosative stress is involved in this process, and that Doxo interacts by amplifying cell damage. Mitochondrial connexin 43 (mitoCx43) can confer cardioprotective eff...

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Detalles Bibliográficos
Autores principales: Pecoraro, Michela, Pala, Barbara, Di Marcantonio, Maria Carmela, Muraro, Raffaella, Marzocco, Stefania, Pinto, Aldo, Mincione, Gabriella, Popolo, Ada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388829/
https://www.ncbi.nlm.nih.gov/pubmed/32705166
http://dx.doi.org/10.3892/ijmm.2020.4669