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Assay development for the discovery of small-molecule inhibitors of YadA adhesion to collagen
We set out to develop scalable assays to measure bacterial adhesion to mammalian extracellular matrix proteins, with the aim to perform high-throughput screening for inhibitors. Our model system is the trimeric autotransporter adhesin YadA from Yersinia enterocolitica that binds to collagen. Using b...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388967/ https://www.ncbi.nlm.nih.gov/pubmed/32743141 http://dx.doi.org/10.1016/j.tcsw.2019.100025 |