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Assay development for the discovery of small-molecule inhibitors of YadA adhesion to collagen

We set out to develop scalable assays to measure bacterial adhesion to mammalian extracellular matrix proteins, with the aim to perform high-throughput screening for inhibitors. Our model system is the trimeric autotransporter adhesin YadA from Yersinia enterocolitica that binds to collagen. Using b...

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Detalles Bibliográficos
Autores principales:	Saragliadis, Athanasios, Linke, Dirk
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388967/ https://www.ncbi.nlm.nih.gov/pubmed/32743141 http://dx.doi.org/10.1016/j.tcsw.2019.100025

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