Confluence of Theory and Experiment Reveal the Catalytic Mechanism of the Varkud Satellite Ribozyme

The Varkud Satellite (VS) ribozyme catalyzes site-specific RNA cleavage and ligation, and serves as an important model system to understand RNA catalysis. Here we combine stereospecific phosphorothioate substitution, precision nucleobase mutation and linear free energy relationship measurements with...

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Detalles Bibliográficos
Autores principales: Ganguly, Abir, Weissman, Benjamin P., Giese, Timothy J., Li, Nan-Sheng, Hoshika, Shuichi, Rao, Saieesh, Benner, Steven A., Piccirilli, Joseph A., York, Darrin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7389185/
https://www.ncbi.nlm.nih.gov/pubmed/31959957
http://dx.doi.org/10.1038/s41557-019-0391-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7389185/
https://www.ncbi.nlm.nih.gov/pubmed/31959957
http://dx.doi.org/10.1038/s41557-019-0391-x

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