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Anti-tubercular derivatives of rhein require activation by the monoglyceride lipase Rv0183

The emergence and perseverance of drug resistant strains of Mycobacterium tuberculosis (Mtb) ensures that drug discovery efforts remain at the forefront of tuberculosis research. There are numerous different approaches that can be employed to lead to the discovery of anti-tubercular agents. In this...

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Detalles Bibliográficos
Autores principales: Abrahams, Katherine A., Hu, Wei, Li, Gang, Lu, Yu, Richardson, Emily J., Loman, Nicholas J., Huang, Haihong, Besra, Gurdyal S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7389528/
https://www.ncbi.nlm.nih.gov/pubmed/32743152
http://dx.doi.org/10.1016/j.tcsw.2020.100040