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Prediction of lisinopril pediatric dose from the reference adult dose by employing a physiologically based pharmacokinetic model
BACKGROUND: This study aimed to assess the pediatric lisinopril doses using an adult physiological based pharmacokinetic (PBPK) model. As the empirical rules of dose calculation cannot calculate gender-specific pediatric doses and ignores the age-related physiological differences. METHODS: A PBPK mo...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7389632/ https://www.ncbi.nlm.nih.gov/pubmed/32727574 http://dx.doi.org/10.1186/s40360-020-00429-y |