BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 are implicated in tau pathology

BACKGROUND: Identified as an Alzheimer’s disease (AD) susceptibility gene by genome wide-association studies, BIN1 has 10 isoforms that are expressed in the Central Nervous System (CNS). The distribution of these isoforms in different cell types, as well as their role in AD pathology still remains u...

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Detalles Bibliográficos
Autores principales: Taga, Mariko, Petyuk, Vladislav A., White, Charles, Marsh, Galina, Ma, Yiyi, Klein, Hans-Ulrich, Connor, Sarah M., Kroshilina, Alexandra, Yung, Christina J., Khairallah, Anthony, Olah, Marta, Schneider, Julie, Karhohs, Kyle, Carpenter, Anne E., Ransohoff, Richard, Bennett, David A., Crotti, Andrea, Bradshaw, Elizabeth M., De Jager, Philip L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7389646/
https://www.ncbi.nlm.nih.gov/pubmed/32727516
http://dx.doi.org/10.1186/s13024-020-00387-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7389646/
https://www.ncbi.nlm.nih.gov/pubmed/32727516
http://dx.doi.org/10.1186/s13024-020-00387-3

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