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FCHSD2 controls oncogenic ERK1/2 signaling outcome by regulating endocytic trafficking
The evolution of transformed cancer cells into metastatic tumors is, in part, driven by altered intracellular signaling downstream of receptor tyrosine kinases (RTKs). The surface levels and activity of RTKs are governed mainly through clathrin-mediated endocytosis (CME), endosomal recycling, or deg...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390455/ https://www.ncbi.nlm.nih.gov/pubmed/32678845 http://dx.doi.org/10.1371/journal.pbio.3000778 |