Cargando…

Decreased Naïve T-cell Production Leading to Cytokine Storm as Cause of Increased COVID-19 Severity with Comorbidities

Aging, type 2 diabetes, and male gender are major risk factors leading to increased COVID-19 morbidity and mortality. Thymic production and the export of naïve T cells decrease with aging through the effects of androgens in males and in type 2 diabetes. Furthermore, with aging, recovery of naïve T-c...

Descripción completa

Detalles Bibliográficos
Autores principales: Schwartz, Michael D, Emerson, Stephen G, Punt, Jennifer, Goff, Willow D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390514/
https://www.ncbi.nlm.nih.gov/pubmed/32765940
http://dx.doi.org/10.14336/AD.2020.0619
_version_ 1783564464775233536
author Schwartz, Michael D
Emerson, Stephen G
Punt, Jennifer
Goff, Willow D
author_facet Schwartz, Michael D
Emerson, Stephen G
Punt, Jennifer
Goff, Willow D
author_sort Schwartz, Michael D
collection PubMed
description Aging, type 2 diabetes, and male gender are major risk factors leading to increased COVID-19 morbidity and mortality. Thymic production and the export of naïve T cells decrease with aging through the effects of androgens in males and in type 2 diabetes. Furthermore, with aging, recovery of naïve T-cell populations after bone marrow transplantation is delayed and associated with an increased risk of chronic graft vs. host disease. Severe COVID-19 and SARS infections are notable for severe T-cell depletion. In COVID-19, there is unique suppression of interferon signaling by infected respiratory tract cells with intact cytokine signaling. A decreased naïve T-cell response likely contributes to an excessive inflammatory response and increases the odds of a cytokine storm. Treatments that improve naïve T-cell production may prove to be vital COVID-19 therapies, especially for these high-risk groups.
format Online
Article
Text
id pubmed-7390514
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher JKL International LLC
record_format MEDLINE/PubMed
spelling pubmed-73905142020-08-05 Decreased Naïve T-cell Production Leading to Cytokine Storm as Cause of Increased COVID-19 Severity with Comorbidities Schwartz, Michael D Emerson, Stephen G Punt, Jennifer Goff, Willow D Aging Dis Commentary Aging, type 2 diabetes, and male gender are major risk factors leading to increased COVID-19 morbidity and mortality. Thymic production and the export of naïve T cells decrease with aging through the effects of androgens in males and in type 2 diabetes. Furthermore, with aging, recovery of naïve T-cell populations after bone marrow transplantation is delayed and associated with an increased risk of chronic graft vs. host disease. Severe COVID-19 and SARS infections are notable for severe T-cell depletion. In COVID-19, there is unique suppression of interferon signaling by infected respiratory tract cells with intact cytokine signaling. A decreased naïve T-cell response likely contributes to an excessive inflammatory response and increases the odds of a cytokine storm. Treatments that improve naïve T-cell production may prove to be vital COVID-19 therapies, especially for these high-risk groups. JKL International LLC 2020-07-23 /pmc/articles/PMC7390514/ /pubmed/32765940 http://dx.doi.org/10.14336/AD.2020.0619 Text en Copyright: © 2020 Schwartz et al. http://creativecommons.org/licenses/by/2.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Commentary
Schwartz, Michael D
Emerson, Stephen G
Punt, Jennifer
Goff, Willow D
Decreased Naïve T-cell Production Leading to Cytokine Storm as Cause of Increased COVID-19 Severity with Comorbidities
title Decreased Naïve T-cell Production Leading to Cytokine Storm as Cause of Increased COVID-19 Severity with Comorbidities
title_full Decreased Naïve T-cell Production Leading to Cytokine Storm as Cause of Increased COVID-19 Severity with Comorbidities
title_fullStr Decreased Naïve T-cell Production Leading to Cytokine Storm as Cause of Increased COVID-19 Severity with Comorbidities
title_full_unstemmed Decreased Naïve T-cell Production Leading to Cytokine Storm as Cause of Increased COVID-19 Severity with Comorbidities
title_short Decreased Naïve T-cell Production Leading to Cytokine Storm as Cause of Increased COVID-19 Severity with Comorbidities
title_sort decreased naïve t-cell production leading to cytokine storm as cause of increased covid-19 severity with comorbidities
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390514/
https://www.ncbi.nlm.nih.gov/pubmed/32765940
http://dx.doi.org/10.14336/AD.2020.0619
work_keys_str_mv AT schwartzmichaeld decreasednaivetcellproductionleadingtocytokinestormascauseofincreasedcovid19severitywithcomorbidities
AT emersonstepheng decreasednaivetcellproductionleadingtocytokinestormascauseofincreasedcovid19severitywithcomorbidities
AT puntjennifer decreasednaivetcellproductionleadingtocytokinestormascauseofincreasedcovid19severitywithcomorbidities
AT goffwillowd decreasednaivetcellproductionleadingtocytokinestormascauseofincreasedcovid19severitywithcomorbidities