Compatibility and Fidelity of Mirror-Image Thymidine in Transcription Events by T7 RNA Polymerase

Due to highly enzymatic d-stereoselectivity, l-nucleotides (l-2′-deoxynucleoside 5′-triphosphates [l-dNTPs]) are not natural targets of polymerases. In this study, we synthesized series of l-thymidine (l-T)-modified DNA strands and evaluated the processivity of nucleotide incorporation for transcrip...

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Detalles Bibliográficos
Autores principales: Liu, Qingju, Ke, Yongqi, Kan, Yuhe, Tang, Xinjing, Li, Xiangjun, He, Yujian, Wu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390857/
https://www.ncbi.nlm.nih.gov/pubmed/32721880
http://dx.doi.org/10.1016/j.omtn.2020.06.023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390857/
https://www.ncbi.nlm.nih.gov/pubmed/32721880
http://dx.doi.org/10.1016/j.omtn.2020.06.023

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