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Compatibility and Fidelity of Mirror-Image Thymidine in Transcription Events by T7 RNA Polymerase
Due to highly enzymatic d-stereoselectivity, l-nucleotides (l-2′-deoxynucleoside 5′-triphosphates [l-dNTPs]) are not natural targets of polymerases. In this study, we synthesized series of l-thymidine (l-T)-modified DNA strands and evaluated the processivity of nucleotide incorporation for transcrip...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390857/ https://www.ncbi.nlm.nih.gov/pubmed/32721880 http://dx.doi.org/10.1016/j.omtn.2020.06.023 |