Imatinib and Dasatinib Provoke Mitochondrial Dysfunction Leading to Oxidative Stress in C2C12 Myotubes and Human RD Cells

Tyrosine kinase inhibitors (TKIs) can cause skeletal muscle toxicity in patients, but the underlying mechanisms are mostly unclear. The goal of the current study was to better characterize the role of mitochondria in TKI-associated myotoxicity. We exposed C2C12 murine myoblasts and myotubes as well...

Descripción completa

Detalles Bibliográficos
Autores principales: Bouitbir, Jamal, Panajatovic, Miljenko Valentin, Frechard, Theo, Roos, Noëmi Johanna, Krähenbühl, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390871/
https://www.ncbi.nlm.nih.gov/pubmed/32792947
http://dx.doi.org/10.3389/fphar.2020.01106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390871/
https://www.ncbi.nlm.nih.gov/pubmed/32792947
http://dx.doi.org/10.3389/fphar.2020.01106

Ejemplares similares