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Partial Activation of TrkB Receptors Corrects Interneuronal Calcium Channel Dysfunction and Reduces Epileptogenic Activity in Neocortex following Injury

Decreased GABAergic inhibition due to dysfunction of inhibitory interneurons plays an important role in post-traumatic epileptogenesis. Reduced N-current Ca(2+) channel function in GABAergic terminals contributes to interneuronal abnormalities and neural circuit hyperexcitability in the partial neoc...

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Detalles Bibliográficos
Autores principales: Gu, Feng, Parada, Isabel, Yang, Tao, Longo, Frank M, Prince, David A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391412/
https://www.ncbi.nlm.nih.gov/pubmed/32488246
http://dx.doi.org/10.1093/cercor/bhz254