Structural effects of the highly protective V127 polymorphism on human prion protein

Prion diseases, a group of incurable, lethal neurodegenerative disorders of mammals including humans, are caused by prions, assemblies of misfolded host prion protein (PrP). A single point mutation (G127V) in human PrP prevents prion disease, however the structural basis for its protective effect re...

Descripción completa

Detalles Bibliográficos
Autores principales: Hosszu, Laszlo L. P., Conners, Rebecca, Sangar, Daljit, Batchelor, Mark, Sawyer, Elizabeth B., Fisher, Stuart, Cliff, Matthew J., Hounslow, Andrea M., McAuley, Katherine, Leo Brady, R., Jackson, Graham S., Bieschke, Jan, Waltho, Jonathan P., Collinge, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391680/
https://www.ncbi.nlm.nih.gov/pubmed/32728168
http://dx.doi.org/10.1038/s42003-020-01126-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391680/
https://www.ncbi.nlm.nih.gov/pubmed/32728168
http://dx.doi.org/10.1038/s42003-020-01126-6

Ejemplares similares