Cargando…
LXR activation potentiates sorafenib sensitivity in HCC by activating microRNA-378a transcription
Sorafenib resistance is a major obstacle to the treatment of advanced hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) are multifunctional regulators of gene expression with profound impact for human disease. Therefore, better understanding of the biological mechanisms of abnormally expressed miRN...
Autores principales: | Lin, Zhongjie, Xia, Shunjie, Liang, Yuelong, Ji, Lin, Pan, Yu, Jiang, Shi, Wan, Zhe, Tao, Liye, Chen, Jiang, Lin, Chengping, Liang, Xiao, Xu, Junjie, Cai, Xiujun |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392029/ https://www.ncbi.nlm.nih.gov/pubmed/32754282 http://dx.doi.org/10.7150/thno.45158 |
Ejemplares similares
-
The microenvironmental and metabolic aspects of sorafenib resistance in hepatocellular carcinoma
por: Xia, Shunjie, et al.
Publicado: (2020) -
TAK1 Is a Novel Target in Hepatocellular Carcinoma and Contributes to Sorafenib Resistance
por: Xia, Shunjie, et al.
Publicado: (2021) -
UBQLN1 mediates sorafenib resistance through regulating mitochondrial biogenesis and ROS homeostasis by targeting PGC1β in hepatocellular carcinoma
por: Xu, Junjie, et al.
Publicado: (2021) -
miR-486-3p mediates hepatocellular carcinoma sorafenib resistance by targeting FGFR4 and EGFR
por: Ji, Lin, et al.
Publicado: (2020) -
LXRα Promotes Hepatosteatosis in Part Through Activation of MicroRNA‐378 Transcription and Inhibition of Ppargc1β Expression
por: Zhang, Tianpeng, et al.
Publicado: (2019)