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Normal human enthesis harbours conventional CD4+ and CD8+ T cells with regulatory features and inducible IL-17A and TNF expression

BACKGROUND: The human enthesis conventional T cells are poorly characterised. OBJECTIVES: To study the biology of the conventional T cells in human enthesis. METHODS: CD4+ and CD8+ T cells were investigated in 25 enthesis samples using immunofluorescence, cytometrically, bulk RNAseq and quantitative...

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Detalles Bibliográficos
Autores principales: Watad, Abdulla, Rowe, Hannah, Russell, Tobias, Zhou, Qiao, Anderson, Lisa K, Khan, Almas, Dunsmuir, Robert, Loughenbury, Peter, Borse, Vishal, Rao, Abhay, Millner, Peter A, Bragazzi, Nicola Luigi, Amital, Howard, Cuhtbert, Richard, Wittmann, Miriam, Sharif, Kassem, Kenna, Tony, Brown, Matthew A, Newton, Darren, Bridgewood, Charlie, McGonagle, Dennis G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392498/
https://www.ncbi.nlm.nih.gov/pubmed/32404344
http://dx.doi.org/10.1136/annrheumdis-2020-217309