Alzheimer’s disease risk gene BIN1 induces Tau-dependent network hyperexcitability

Genome-wide association studies identified the BIN1 locus as a leading modulator of genetic risk in Alzheimer’s disease (AD). One limitation in understanding BIN1’s contribution to AD is its unknown function in the brain. AD-associated BIN1 variants are generally noncoding and likely change expressi...

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Detalles Bibliográficos
Autores principales: Voskobiynyk, Yuliya, Roth, Jonathan R, Cochran, J Nicholas, Rush, Travis, Carullo, Nancy VN, Mesina, Jacob S, Waqas, Mohammad, Vollmer, Rachael M, Day, Jeremy J, McMahon, Lori L, Roberson, Erik D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392604/
https://www.ncbi.nlm.nih.gov/pubmed/32657270
http://dx.doi.org/10.7554/eLife.57354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392604/
https://www.ncbi.nlm.nih.gov/pubmed/32657270
http://dx.doi.org/10.7554/eLife.57354

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