Synaptic RTP801 contributes to motor-learning dysfunction in Huntington’s disease

RTP801/REDD1 is a stress-responsive protein that mediates mutant huntingtin (mhtt) toxicity in cellular models and is up regulated in Huntington’s disease (HD) patients’ putamen. Here, we investigated whether RTP801 is involved in motor impairment in HD by affecting striatal synaptic plasticity. To...

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Detalles Bibliográficos
Autores principales: Martín-Flores, Núria, Pérez-Sisqués, Leticia, Creus-Muncunill, Jordi, Masana, Mercè, Ginés, Sílvia, Alberch, Jordi, Pérez-Navarro, Esther, Malagelada, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392897/
https://www.ncbi.nlm.nih.gov/pubmed/32732871
http://dx.doi.org/10.1038/s41419-020-02775-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392897/
https://www.ncbi.nlm.nih.gov/pubmed/32732871
http://dx.doi.org/10.1038/s41419-020-02775-5

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