Escape from nonsense-mediated decay associates with anti-tumor immunogenicity

Frameshift insertion/deletions (fs-indels) are an infrequent but highly immunogenic mutation subtype. Although fs-indels are degraded through the nonsense-mediated decay (NMD) pathway, we hypothesise that some fs-indels escape degradation and elicit anti-tumor immune responses. Using allele-specific...

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Detalles Bibliográficos
Autores principales: Litchfield, Kevin, Reading, James L., Lim, Emilia L., Xu, Hang, Liu, Po, Al-Bakir, Maise, Wong, Yien Ning Sophia, Rowan, Andrew, Funt, Samuel A., Merghoub, Taha, Perkins, David, Lauss, Martin, Svane, Inge Marie, Jönsson, Göran, Herrero, Javier, Larkin, James, Quezada, Sergio A., Hellmann, Matthew D., Turajlic, Samra, Swanton, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393139/
https://www.ncbi.nlm.nih.gov/pubmed/32733040
http://dx.doi.org/10.1038/s41467-020-17526-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393139/
https://www.ncbi.nlm.nih.gov/pubmed/32733040
http://dx.doi.org/10.1038/s41467-020-17526-5

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