Metformin Mitigates Cartilage Degradation by Activating AMPK/SIRT1-Mediated Autophagy in a Mouse Osteoarthritis Model

Chondrocyte dysfunction is a key mechanism underlying osteoarthritis. Metformin has shown protective effects in many diseases. The present study aimed to investigate the effects of metformin on autophagy and apoptosis in the process of osteoarthritis. A mouse osteoarthritis model was set up by surgi...

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Detalles Bibliográficos
Autores principales: Wang, Chenzhong, Yao, Zhenjun, Zhang, Yueqi, Yang, Yi, Liu, Jinyu, Shi, Yi, Zhang, Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393141/
https://www.ncbi.nlm.nih.gov/pubmed/32792951
http://dx.doi.org/10.3389/fphar.2020.01114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393141/
https://www.ncbi.nlm.nih.gov/pubmed/32792951
http://dx.doi.org/10.3389/fphar.2020.01114

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