The Art and Science of Selecting a CD123-Specific Chimeric Antigen Receptor for Clinical Testing

Chimeric antigen receptor (CAR) T cells targeting CD123, an acute myeloid leukemia (AML) antigen, hold the promise of improving outcomes for patients with refractory/recurrent disease. We generated five lentiviral vectors encoding CD20, which may serve as a target for CAR T cell depletion, and 2(nd)...

Descripción completa

Detalles Bibliográficos
Autores principales: Riberdy, Janice M., Zhou, Sheng, Zheng, Fei, Kim, Young-In, Moore, Jennifer, Vaidya, Abishek, Throm, Robert E., Sykes, April, Sahr, Natasha, Bonifant, Challice L., Ryu, Byoung, Gottschalk, Stephen, Velasquez, Mireya Paulina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393323/
https://www.ncbi.nlm.nih.gov/pubmed/32775492
http://dx.doi.org/10.1016/j.omtm.2020.06.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393323/
https://www.ncbi.nlm.nih.gov/pubmed/32775492
http://dx.doi.org/10.1016/j.omtm.2020.06.024

Ejemplares similares