A FRET-based screening method to detect potential inhibitors of the binding of CNNM3 to PRL2

The cyclin M (CNNM) family of Mg(2+) transporters is reported to promote tumour progression by binding to phosphatase of regenerating liver (PRL) proteins. Here, we established an assay for detection of the binding between the cystathionine-beta-synthase (CBS) domain of human CNNM3 (a region respons...

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Detalles Bibliográficos
Autores principales: Cai, Faji, Huang, Yichen, Wang, Mengqi, Sun, Minxuan, Zhao, Yimeng, Hattori, Motoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393355/
https://www.ncbi.nlm.nih.gov/pubmed/32733084
http://dx.doi.org/10.1038/s41598-020-69818-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393355/
https://www.ncbi.nlm.nih.gov/pubmed/32733084
http://dx.doi.org/10.1038/s41598-020-69818-x

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