Activating PIK3CA mutation promotes adipogenesis of adipose-derived stem cells in macrodactyly via up-regulation of E2F1

Macrodactyly is a congenital malformation characterized by enlargement of bone and soft tissues in limbs, typically with excessive accumulation of adipose tissues. Although gain-of-function mutation of PIK3CA has been identified in macrodactyly, the mechanism of PIK3CA mutation in adipose accumulati...

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Detalles Bibliográficos
Autores principales: Sun, Bin, Jiang, Yongkang, Cui, Hengqing, Fang, Xia, Han, Gang, Dai, Xinyi, Zhou, Shengbo, Mao, Hailei, Wang, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393369/
https://www.ncbi.nlm.nih.gov/pubmed/32732866
http://dx.doi.org/10.1038/s41419-020-02806-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393369/
https://www.ncbi.nlm.nih.gov/pubmed/32732866
http://dx.doi.org/10.1038/s41419-020-02806-1

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