Loss of Function Genetic Screen Identifies ATM Kinase as a Positive Regulator of TLR3-Mediated NF-κB Activation

TLR3, a major innate immune pattern recognition receptor of RNA viruses, triggers inflammatory response through the transcription factor NF-κB. However, a genome-wide understanding of the genes and mechanisms regulating TLR3-mediated NF-κB activation is incomplete. We herein report the results of a...

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Detalles Bibliográficos
Autores principales: Unniyampurath, Unnikrishnan, Crisci, Angela, Krishnan, Manoj N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393402/
https://www.ncbi.nlm.nih.gov/pubmed/32731169
http://dx.doi.org/10.1016/j.isci.2020.101356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393402/
https://www.ncbi.nlm.nih.gov/pubmed/32731169
http://dx.doi.org/10.1016/j.isci.2020.101356

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