Heart Failure With Reduced Ejection Fraction Is Characterized by Systemic NEP Downregulation

Based on the investigation of neprilysin (NEP) regulation in a translational porcine model of chronic heart failure (HF), this study concluded: 1) that kidneys might play a crucial part in systemic NEP regulation based on 20 to 100 higher NEP content and/or activity compared with any other organ; 2)...

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Detalles Bibliográficos
Autores principales: Pavo, Imre J., Pavo, Noemi, Kastner, Nina, Traxler, Denise, Lukovic, Dominika, Zlabinger, Katrin, Spannbauer, Andreas, Riesenhuber, Martin, Lorant, David, Bartko, Philipp E., Goliasch, Georg, Hülsmann, Martin, Winkler, Johannes, Gyöngyösi, Mariann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393434/
https://www.ncbi.nlm.nih.gov/pubmed/32760858
http://dx.doi.org/10.1016/j.jacbts.2020.05.011
Descripción
Sumario:Based on the investigation of neprilysin (NEP) regulation in a translational porcine model of chronic heart failure (HF), this study concluded: 1) that kidneys might play a crucial part in systemic NEP regulation based on 20 to 100 higher NEP content and/or activity compared with any other organ; 2) NEP seems to be downregulated under HF conditions; and 3) that the value of plasma NEP concentrations and activity as biomarkers is questionable. For the first time, these data provide basic knowledge on HF-related pathophysiological alterations of the NEP system and contribute to understanding the mechanism of action of angiotensin-receptor neprilysin-inhibitors, which remains elusive despite broad clinical applications.

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