Preventing ATP Degradation by ASO-Mediated Knockdown of CD39 and CD73 Results in A2aR-Independent Rescue of T Cell Proliferation

The adenosine axis contributes to the suppression of antitumor immune responses. The ectonucleotidase CD39 degrades extracellular adenosine triphosphate (ATP) to adenosine monophosphate (AMP), which is degraded to adenosine by CD73. Adenosine binds to, e.g., the A2a receptor (A2aR), which reportedly...

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Detalles Bibliográficos
Autores principales: Festag, Julia, Thelemann, Tamara, Schell, Monika, Raith, Stefanie, Michel, Sven, Jaschinski, Frank, Klar, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393471/
https://www.ncbi.nlm.nih.gov/pubmed/32739778
http://dx.doi.org/10.1016/j.omtn.2020.06.020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393471/
https://www.ncbi.nlm.nih.gov/pubmed/32739778
http://dx.doi.org/10.1016/j.omtn.2020.06.020

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