SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach

It is challenging to identify somatic variants from high-throughput sequence reads due to tumor heterogeneity, sub-clonality, and sequencing artifacts. In this study, we evaluated the performance of eight primary somatic variant callers and multiple ensemble methods using both real and synthetic who...

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Detalles Bibliográficos
Autores principales: Wang, Mingyi, Luo, Wen, Jones, Kristine, Bian, Xiaopeng, Williams, Russell, Higson, Herbert, Wu, Dongjing, Hicks, Belynda, Yeager, Meredith, Zhu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393490/
https://www.ncbi.nlm.nih.gov/pubmed/32732891
http://dx.doi.org/10.1038/s41598-020-69772-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393490/
https://www.ncbi.nlm.nih.gov/pubmed/32732891
http://dx.doi.org/10.1038/s41598-020-69772-8

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