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SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach
It is challenging to identify somatic variants from high-throughput sequence reads due to tumor heterogeneity, sub-clonality, and sequencing artifacts. In this study, we evaluated the performance of eight primary somatic variant callers and multiple ensemble methods using both real and synthetic who...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393490/ https://www.ncbi.nlm.nih.gov/pubmed/32732891 http://dx.doi.org/10.1038/s41598-020-69772-8 |