Loss of Caveolin-1 and caveolae leads to increased cardiac cell stiffness and functional decline of the adult zebrafish heart

Caveolin-1 is the main structural protein of caveolae, small membrane invaginations involved in signal transduction and mechanoprotection. Here, we generated cav1-KO zebrafish lacking Cav1 and caveolae, and investigated the impact of this loss on adult heart function and response to cryoinjury. We f...

Descripción completa

Detalles Bibliográficos
Autores principales: Grivas, Dimitrios, González-Rajal, Álvaro, Guerrero Rodríguez, Carlos, Garcia, Ricardo, de la Pompa, José Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393500/
https://www.ncbi.nlm.nih.gov/pubmed/32733088
http://dx.doi.org/10.1038/s41598-020-68802-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393500/
https://www.ncbi.nlm.nih.gov/pubmed/32733088
http://dx.doi.org/10.1038/s41598-020-68802-9

Ejemplares similares