Functional 3D architecture in an intrinsically disordered E3 ligase domain facilitates ubiquitin transfer

The human genome contains an estimated 600 ubiquitin E3 ligases, many of which are single-subunit E3s (ssE3s) that can bind to both substrate and ubiquitin-loaded E2 (E2~Ub). Within ssE3s structural disorder tends to be located in substrate binding and domain linking regions. RNF4 is a ssE3 ligase w...

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Detalles Bibliográficos
Autores principales: Murphy, Paul, Xu, Yingqi, Rouse, Sarah L., Jaffray, Ellis G., Plechanovová, Anna, Matthews, Steve J., Carlos Penedo, J., Hay, Ronald T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393505/
https://www.ncbi.nlm.nih.gov/pubmed/32733036
http://dx.doi.org/10.1038/s41467-020-17647-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393505/
https://www.ncbi.nlm.nih.gov/pubmed/32733036
http://dx.doi.org/10.1038/s41467-020-17647-x

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