Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms

Iron homeostasis is essential for health; moreover, hepcidin-deficiency results in iron overload in both hereditary hemochromatosis and iron-loading anemia. Here, we identified iron modulators by functionally screening hepcidin agonists using a library of 640 FDA-approved drugs in human hepatic Huh7...

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Detalles Bibliográficos
Autores principales: Yang, Lei, Wang, Hao, Yang, Xiang, Wu, Qian, An, Peng, Jin, Xi, Liu, Weiwei, Huang, Xin, Li, Yuzhu, Yan, Shiyu, Shen, Shuying, Liang, Tingbo, Min, Junxia, Wang, Fudi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393508/
https://www.ncbi.nlm.nih.gov/pubmed/32732975
http://dx.doi.org/10.1038/s41392-020-00253-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393508/
https://www.ncbi.nlm.nih.gov/pubmed/32732975
http://dx.doi.org/10.1038/s41392-020-00253-0

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