Cargando…
Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration
BACKGROUND: Neuronal damage in acute CNS injuries and chronic neurodegenerative diseases is invariably accompanied by an astrocyte reaction in both mice and humans. However, whether and how the nature of the CNS insult—acute versus chronic—influences the astrocyte response, and whether astrocyte tra...
Autores principales: | Das, Sudeshna, Li, Zhaozhi, Noori, Ayush, Hyman, Bradley T., Serrano-Pozo, Alberto |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393869/ https://www.ncbi.nlm.nih.gov/pubmed/32736565 http://dx.doi.org/10.1186/s12974-020-01898-y |
Ejemplares similares
-
Systematic review and meta-analysis of human transcriptomics reveals neuroinflammation, deficient energy metabolism, and proteostasis failure across neurodegeneration
por: Noori, Ayush, et al.
Publicado: (2020) -
Systematic review of human post‐mortem immunohistochemical studies and bioinformatics analyses unveil the complexity of astrocyte reaction in Alzheimer's disease
por: Viejo, Lucía, et al.
Publicado: (2021) -
Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer’s disease
por: Muñoz-Castro, Clara, et al.
Publicado: (2022) -
Differential gene expression data from the human central nervous system across Alzheimer's disease, Lewy body diseases, and the amyotrophic lateral sclerosis and frontotemporal dementia spectrum
por: Noori, Ayush, et al.
Publicado: (2021) -
Distinct Transcriptomic Responses to Aβ plaques, Neurofibrillary Tangles, and APOE in Alzheimer’s Disease
por: Das, Sudeshna, et al.
Publicado: (2023)