Structure-guided screening strategy combining surface plasmon resonance with nuclear magnetic resonance for identification of small-molecule Argonaute 2 inhibitors

Argonaute (AGO) proteins are the key component of the RNA interference machinery that suppresses gene expression by forming an RNA-induced silencing complex (RISC) with microRNAs (miRNAs). Each miRNA is involved in various cellular processes, such as development, differentiation, tumorigenesis, and...

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Detalles Bibliográficos
Autores principales: Harumoto, Toshimasa, Sato, Atsuko, Takayama, Yuki, Miyagi, Hikaru, Saito, Jun-ichi, Shinohara, Fumikazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394379/
https://www.ncbi.nlm.nih.gov/pubmed/32735606
http://dx.doi.org/10.1371/journal.pone.0236710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394379/
https://www.ncbi.nlm.nih.gov/pubmed/32735606
http://dx.doi.org/10.1371/journal.pone.0236710

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