Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA

Mutations that cause Huntington’s Disease involve a polyglutamine (polyQ) sequence expansion beyond 35 repeats in exon 1 of Huntingtin. Intracellular inclusion bodies of mutant Huntingtin protein are a key feature of Huntington’s disease brain pathology. We previously showed that in cell culture the...

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Detalles Bibliográficos
Autores principales: Ormsby, Angelique R., Cox, Dezerae, Daly, James, Priest, David, Hinde, Elizabeth, Hatters, Danny M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394408/
https://www.ncbi.nlm.nih.gov/pubmed/32735619
http://dx.doi.org/10.1371/journal.pone.0233583

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394408/
https://www.ncbi.nlm.nih.gov/pubmed/32735619
http://dx.doi.org/10.1371/journal.pone.0233583

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