Liraglutide Attenuates Aβ42 Generation in APPswe/SH-SY5Y Cells Through the Regulation of Autophagy

OBJECTIVE: This study aimed to clarify whether liraglutide, a GLP-1 analogue, can ameliorate Aβ pathology through the regulation of autophagy in Alzheimer’s disease (AD) and to explore the related mechanisms thereof. METHODS: We used SH-SY5Y cells transiently transfected with APP695swe plasmid as an...

Descripción completa

Detalles Bibliográficos
Autores principales: Kong, Jingjing, Wan, Liping, Wang, Yanfu, Zhang, Hua, Zhang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394597/
https://www.ncbi.nlm.nih.gov/pubmed/32801716
http://dx.doi.org/10.2147/NDT.S260160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394597/
https://www.ncbi.nlm.nih.gov/pubmed/32801716
http://dx.doi.org/10.2147/NDT.S260160

Ejemplares similares