An adverse outcome pathway for immune-mediated and allergic hepatitis: a case study with the NSAID diclofenac

Many drugs have the potential to cause drug-induced liver injury (DILI); however, underlying mechanisms are diverse. The concept of adverse outcome pathways (AOPs) has become instrumental for risk assessment of drug class effects. We report AOPs specific for immune-mediated and drug hypersensitivity...

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Detalles Bibliográficos
Autores principales: Selvaraj, Saravanakumar, Oh, Jung-Hwa, Borlak, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Immunotoxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395045/
https://www.ncbi.nlm.nih.gov/pubmed/32372211
http://dx.doi.org/10.1007/s00204-020-02767-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395045/
https://www.ncbi.nlm.nih.gov/pubmed/32372211
http://dx.doi.org/10.1007/s00204-020-02767-6

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