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An adverse outcome pathway for immune-mediated and allergic hepatitis: a case study with the NSAID diclofenac
Many drugs have the potential to cause drug-induced liver injury (DILI); however, underlying mechanisms are diverse. The concept of adverse outcome pathways (AOPs) has become instrumental for risk assessment of drug class effects. We report AOPs specific for immune-mediated and drug hypersensitivity...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395045/ https://www.ncbi.nlm.nih.gov/pubmed/32372211 http://dx.doi.org/10.1007/s00204-020-02767-6 |