The evolution of strategies to minimise the risk of human drug-induced liver injury (DILI) in drug discovery and development

Early identification of toxicity associated with new chemical entities (NCEs) is critical in preventing late-stage drug development attrition. Liver injury remains a leading cause of drug failures in clinical trials and post-approval withdrawals reflecting the poor translation between traditional pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Walker, Paul A., Ryder, Stephanie, Lavado, Andrea, Dilworth, Clive, Riley, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395068/
https://www.ncbi.nlm.nih.gov/pubmed/32372214
http://dx.doi.org/10.1007/s00204-020-02763-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395068/
https://www.ncbi.nlm.nih.gov/pubmed/32372214
http://dx.doi.org/10.1007/s00204-020-02763-w

Ejemplares similares