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The evolution of strategies to minimise the risk of human drug-induced liver injury (DILI) in drug discovery and development
Early identification of toxicity associated with new chemical entities (NCEs) is critical in preventing late-stage drug development attrition. Liver injury remains a leading cause of drug failures in clinical trials and post-approval withdrawals reflecting the poor translation between traditional pr...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395068/ https://www.ncbi.nlm.nih.gov/pubmed/32372214 http://dx.doi.org/10.1007/s00204-020-02763-w |