Tuning mTORC1 activity dictates the response of acute myeloid leukemia to LSD1 inhibition

Lysine specific demethylase-1 (LSD1) has been shown to be critical in acute myeloid leukemia (AML) pathogenesis and this has led to the development of LSD1 inhibitors (LSD1i) which are currently tested in clinical trials. Nonetheless, preclinical studies reported that AML cells frequently exhibit in...

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Detalles Bibliográficos
Autores principales: Abdel-Aziz, Amal Kamal, Pallavicini, Isabella, Ceccacci, Elena, Meroni, Giuseppe, Saadeldin, Mona Kamal, Varasi, Mario, Minucci, Saverio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395280/
https://www.ncbi.nlm.nih.gov/pubmed/31537694
http://dx.doi.org/10.3324/haematol.2019.224501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395280/
https://www.ncbi.nlm.nih.gov/pubmed/31537694
http://dx.doi.org/10.3324/haematol.2019.224501

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