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Molecular Structure and Function of Janus Kinases: Implications for the Development of Inhibitors

Cytokines can trigger multiple signalling pathways, including Janus tyrosine kinases [JAK] and signal transducers and activators of transcription [STATS] pathways. JAKs are cytoplasmic proteins that, following the binding of cytokines to their receptors, transduce the signal by phosphorylating STAT...

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Detalles Bibliográficos
Autores principales: Garrido-Trigo, Alba, Salas, Azucena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395311/
https://www.ncbi.nlm.nih.gov/pubmed/32083640
http://dx.doi.org/10.1093/ecco-jcc/jjz206